Hepatocellular carcinoma: development and early detection

Hepatocellular carcinoma: development and early detection

Our eventual aim is to predict, using non-invasive imaging techniques, the biological behaviour of individual cirrhotic nodules. We are some distance away from this, so our current objective is to define imaging features which predict the histologic findings. This short review summarises the current capabilities and limitations of non-invasive imaging in detecting small hepatocellular carcinoma...

Early hepatocellular carcinoma

Hepatocellular carcinoma may develop from multistep carcinogenesis via dysplastic nodules in the cirrhotic liver. The first stage between high-grade dysplastic nodule to overt hepatocellular carcinoma is vaguely nodular, early hepatocellular carcinoma. The consensus on the nomenclature and pathologic characteristics of both entities were recently established by an international consensus group ...

Hepatocellular Carcinoma in Sheep

New Biomarkers for Early Detection of Hepatocellular Carcinoma

Although considerable progress has been made in treatments of (Hong et al., 2015). Anti-TAA antibodies might reflect molecular events hepatocellular carcinoma (HCC), no effective systemic cytotoxic chemotherapy has been established (Lopez et al., 2006). Surgical resection or percutaneous intervention (radiofrequency ablation and ethanol injection) therapy is effective only at an early stage of ...

Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.

Changes in glycosylation, most notably fucosylation, have been associated with the development of hepatocellular carcinoma (HCC). In this report, the levels of fucosylated kininogen (Fc-Kin) and fucosylated alpha-1-antitrypsin were analyzed individually and in combination with the currently used marker, alpha-fetoprotein, and a previously identified biomarker, Golgi protein 73 (GP73), for the a...